The majority of runners develop running-related injuries. Patellofemoral pain (PFP) ranks among the common conditions in individuals with running-related injuries. Education on managing training loads is believed to be a main component for treating runners with PFP. In addition, multimodal interventions are recommended to treat runners with PFP. However to date, the relative contribution of treatment components and the influence on the clinical outcome has not been addressed. Thus, this study compared different rehabilitation approaches in runners with PFP.