Exercise-related injuries occur commonly and, although many interventions have been used to prevent these injuries, only limited evidence supports their effect. Foot orthoses and shock-absorbing insoles are 2 of these treatments. Foot orthoses have been used to optimise the foot function and showed to alter plantar pressure distribution, activity and kinematics of the lower limb during walking and running. Shock-absorbing insoles are designed to reduce impact forces. This systematic review aimed to to estimate the effectiveness of foot orthoses and shock-absorbing insoles for the prevention of musculoskeletal injury.